Chemical and Toxicological Diagnosis of Acute Poisoning with Doxylamine, Zaleplon, and Phenazepam

BACKGROUND The market of hypnotic and sedative drugs is being updated due to the high toxicity barbiturates limitations their use. Currently, safer such as Z-drugs, Doxylamine, some benzodiazepine derivatives are often prescribed for treatment anxiety insomnia, but they can cause acute poisoning if overdosed or in case nonmedical AIM To establish an affordable express thin-layer chromatography (TLC) technique preliminary screening detection Phenazepam Zaleplon order diagnose poisoning. MATERIAL AND METHODS Thin-layer gas with mass selective (GC-MS) methods were used. Urine samples from patients symptoms Zaleplon, poisoning, model urine prepared by liquid-liquid extraction at pH 9.0 chloroform TLC analysis, ethyl acetate-diethyl ether mixture (1:1) GC-MS. RESULTS We developed method which helps reveal presence patient’s urine, well distinguish one another similar toxic symptoms. GC-MS was used confirmatory analysis. Compared methods, expressive, does not require expensive high-tech equipment, while allowing differentiate each other toxicologically significant psychoactive substances detected general screening.